The Bulldogs are looking to clinch their fifth win of the season while the Rabbitohs are missing two of their starting stars.
Souths is out after NSW star Cameron Murray suffered a head knock in the opening decider.
Match Centre: Bulldogs v Rabbitohs, result, teams, video, stats
The Blues are also missing rested winger Damien Cook, who played just 28 minutes on Wednesday.
Davvy Moale moved on to lock up Sylva Havili, replacing Cook at Harlot.
Canterbury young gun Aaron Schupp has replaced Dylan Casey after testing positive for Covid.
Bulldogs 1. Jake Averillo 2. Jacob Kiraz 20. Declan Casey 4. Braydon Burns 5. Josh Addo-Carr 6. Matt Burton 7. Kyle Flanagan 8. Max King 9. Jeremy Marshall-King 10. Paul Vaughan 11. Josh Jackson 12. Corey Waddell 13. Tevita Pangai Jr. 14. Zach Docker-Clay 15. Kurtz Morin 16. Joe Stimson 17. Raymond Fitala-Mariner 19. Matt Dufty 23. Chris Pattolo
Rabbitohs: 1. Latrell Mitchell 2. Alex Johnston 3. Thane Milne 4. Isaiah Taas 5. Jackson Paulo 6. Cody Walker 7. Lachlan Elias 8. Tevita Tatola 16. Silva Havili 10. Mark Nicholls 11. Keon Kolomatangi 12. Movielle Darrow 14. Cody Nikorima 15. Jade Cartwright 17. Thomas Burgess 18. Daniel Suluka-Fifita 22. Blake Taffe 23. Ben Lovett
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