The Titans endured a torrid start after the full game but managed to lead the Cavaliers 30-14 after 55 minutes.
Two minutes after Newcastle’s cross, Anthony Milford rose above opposite number Corey Thompson and fired in a corner for Edric Lee.
Match Centre: Titans vs Knights Teams, Super Coach Results, Videos, Updates
But the Titans took the lead in the 13th minute with quick-fire tries from Greg Marzu and David Fifita.
Marzo broke through thanks to a clever grubber from AJ Brimson, and Campbell set up Fitta to do his best to handle from seven yards out.
The pair are the worst defensive team in the NRL and their fourth try came in the 25th minute when Knights prop Daniel Saifiti crashed over from close range.
Brimson set up another beautiful ball and charged Beau Fermore into the hole on the stroke of half-time, speeding in the corner to score.
Minutes later, after Marzu bagged the double, teenager Tanah Boyd put in a cross-court bomb that was collected by Campbell.
Boyd then scored one of his own after half-time after he advanced Tino Fa’asuamaleaui 10 yards out.
“Good start from the Titans, can Newcastle come back? I’d say no,” Gregg Alexander said at halftime on Fox League.
But it was the Knights who struck first in the second half when Jayden Brealey burst through the middle and Dom Young went wide.
Brimson then got his name on the scoreboard as Dane Gagan rose to break down the left wing before Brian Kelly found the 6th inside the box.
“AJ Brimson, what an afternoon he’s having. He’s always there, he’s never out of the game,” Mick Ennis said on Fox League.
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The Gold Coast Titans host the Newcastle Knights in a clash at Cbus Super Stadium.
Titans winger Phillip Sammy is ruled out due to concussion protocols, with Corey Thompson taking his place.
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Listen to the full Jackson Hastings interview on the Fox League podcast
Patrick Herbert is out with a knee injury and Brian Kelly is on his way back from a knee injury.
The Cavaliers have moved Matt Crocker and Daniel Saifiti to the bench with Tyson Frizzell returning from a rib injury and Daniel Saifiti from covid protocols.
The Titans must win to put breathing space between them and the Wooden Spoon, while the Knights can avoid the Spoon by winning.