The Rabbitohs will be looking to renew their finals charge against the Warriors on Saturday afternoon after their four-game winning streak ended last week with a golden point.
The Colts, on the other hand, have won just one of their last 11 games and will be looking to salvage what they can from another postseason absence.
Match Centre: Rabbitohs v Warriors, Results, Teams, Videos, Stats
The Browns will hand 25-year-old Isaac Thompson his debut after the winger came into the side having scored 20 tries in 16 reserve games this season.
Thompson He took a four-year break from rugby league between 2017 and 2021 and his numbers in the NSW Cup this season were no exception, averaging around 150 running meters per game.
Jackson Paulo moved to the centres, Thompson on the wing and Thane Milne dropped to 18th man.
Alyssa Katowa completed the match, Adam Pompey moved to 18th man and Jackson Frey was promoted to the bench.
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The Rabbitohs Team: 1. Latrell Mitchell 2. Alex Johnston 4. Isaiah Taas 5. Jackson Paulo 18. Isaac Thompson 6. Cody Walker 7. Lachlan Elias 8. Tevita Tatola 9. Damien Cook 10. Daniel Suluka-Fifita 11. Keon Koloamatani Arrow 13. Cameron Murray 14. Blake Taaffe 15. Davy Moale 16. Silver Havili 17. Mark Nicholls 3. Thane Milne
A group of warriors: 1. Reece Walsh 2. Dallin Watene-Zelezniak 3. Marcelo Montoya 4. Eun Aitken 5. Edward Causey 6. Wayde Egan 7. Shaun Johnson 8. Addin Fonua-Black 9. Freddie Lucic 10. Tohu Harris 11. Bailey Sirone 12. Jack Murchie 13. Aaron Penn 14. Tanila Otukolo 15. Bunty Afoa 17. Josh Curran 18. Jackson Frey 22. Adam Pompey